lyox.com

  • Quantitative Systems Pharmacology Modelling Expert

    Quantitative Systems Pharmacology Modeler

    We are looking for a highly motivated data scientist and mathematical modeller with a Masters or PhD degree who wants to impact how drugs are developed today. If you have great computational skills and dare to use them for tackling the complex biology underlying human disease; then LYO-X is the right place for you.

    LYO-X is an established Swiss company located in Basel providing consulting and Quantitative Systems Pharmacology modelling services for the preclinical and clinical development of drugs to our customers worldwide. Our customers are highly innovative biotechnology companies as well as international pharmaceutical companies and non-profit health organizations. LYO-X is one of the very few companies globally that is successfully applying Quantitative Systems Pharmacology as a service to help develop the next generation drugs. 

    We seek individuals with excellent analytical and conceptual skills with a background in engineering, biophysics, computational sciences or other related fields. Experience in life science, pharmacology or drug development is advantageous but not required. This position is for above average candidates with a recent Master’s or PhD degree from the ETHZ, EPFL or another top class university.

    Required skills: 

    • Rigorous, excellent analytical skills, pro-active
    • Good at communication of scientific topics 
    • Proficient in oral and written English
    • Expert in scientific programming using Matlab and R
    • Confident in understanding, using and solving ordinary differential equations (ODE)
    • Other versatile computational skills are desired in fields such as image processing, partial differential equations (PDE), machine learning, statistical learning or parallel computing

    At LYO-X, you can maximize your individual potential and expertise while pursuing a career that reflects your passions and lifestyle.

    If you are interested and would like to contribute to the growth of LYO-X, we would be pleased to receive your application including a letter of application, curriculum vitae, academic transcripts and job references. Please send your application to machacek@lyo-x.com.

     

  • Systems Pharmacology Internship

    Software for animal-to-human scaling of biotherapeutics

    Project:

    Animal-to-human scaling of novel biotherapeutics is an important step in drug development. We want to develop a software that integrates existing data on preclinical and clinical pharmacokinetics of different biotherapeutic formats with mathematical models. The software should be able to visualize pharmacokinetic profiles across different species and provide model predictions in animal and in human.

    Internship Goals:

    • Review literature on monoclonal antibody kinetics in preclinical species and in human.
    • Digitize literature data and build a pharmacokinetics data base.
    • Develop mathematical models.
    • Develop an interface to query data and mathematical models for the prediction in humans.

    Requirements:

    • Rigorous, excellent analytical skills, pro-active.
    • Entrepreneurial spirit.
    • Good at communication of scientific topics.
    • Proficient in oral and written English.
    • Good mathematical and statistical skills.
    • Expert in scientific programming using R and Shiny.
    • User interface design.

    Languages:

    English (Advanced)

    Location:

    Allschwil. Remote work possible after evaluation of situation.

    Company:

    LYO-X is a Swiss company located in Basel providing global consulting and Systems Pharmacology modelling services dedicated to the preclinical and clinical development of biologics and cell-based therapies.

    Contact:

    Dr. Matthias Machacek (career@lyo-x.com)

  • Systems Pharmacology Internship

    Simulation software for antibiotics effect prediction

    Project:

    Antibiotics resistance is a huge issue that is also getting more public awareness due to its criticality. An important part of addressing this problem is the correct usage of antibiotics. For this one has to know if an antibiotic is effective against a certain bacterial strain and how it should be dosed. We are implementing a software platform that allows users to predict the probability of successful treatment based on the bacterial strain and the type of drug and the dose and regimen. This software should be accessible via a web interface that is programmed in R and Shiny.

    Internship Goals:

    1. Implement a mathematical model of antibiotics pharmacokinetics.
    2. Implement a mathematical model of antibiotics effect.
    3. Develop an interface in shiny for the mathematical models.
    4. Rigorous testing of the interface for usability.

    Requirements:

    • Rigorous, excellent analytical skills, pro-active.
    • Entrepreneurial spirit.
    • Good at communication of scientific topics.
    • Proficient in oral and written English.
    • Good mathematical and statistical skills.
    • Expert in scientific programming using R and Shiny.
    • User interface design.

    Languages:

    English (Advanced)

    Location:

    Allschwil. Remote work possible after evaluation of situation.

    Company:

    LYO-X is a Swiss company located in Basel providing global consulting and Systems Pharmacology modelling services dedicated to the preclinical and clinical development of biologics and cell-based therapies. 

    Contact:

    Dr. Matthias Machacek (career@lyo-x.com)

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